SCIENCE & STUDIES

Traditional wisdom, examined by modern research.

<p>Every ingredient in RootPulse has a documented history — both in traditional use and in the clinical literature. Here's an overview of what we rely on.</p>

Four Pillars of Our Quality

STUDY-BASED ACTIVE SUBSTANCES
INDEPENDENTLY LAB-TESTED
CLEAN FORMULA
MADE IN EU
100% Vegan GMP-certified Novel Food compliant DIN EN ISO 17025
700+ Years of hawthorn in European herbal medicine
Come. E Hawthorn Monograph (Federal Gazette 1994)
35+ Meta-analyzed RCTs on Curcumin & Endothelial Function
MK-7 Half-life 72 h — the superior vitamin K2 form
Back to product

90-day satisfaction guarantee

STUDIES IN DETAIL

What the studies specifically show

Four studies investigating the effect of individual active ingredients from RootPulse VITAL5 on systolic and diastolic blood pressure. The figures are mean values compared to placebo.

Active substance · Endothelium

Cayenne Extract (Capsaicin)

Activates TRPV1 receptors in the vessel walls, thereby inducing direct relaxation of the vascular muscles. It particularly affects the smallest vessels — the capillaries, which standard blood pressure medications do not reach.

Study 2021 · Hypertensive Patients · 16 Weeks
-4.6
mmHg systolic
-3.2
mmHg diastolic

Placebo group: no change.

Active substance · Endothelium

Beetroot extract

The best natural source of nitrates. The body converts nitrates into nitric oxide – the molecule that keeps blood vessels wide and elastic. It even works when the endothelium is already damaged.

Meta-analysis 2007 · over 350 participants · 88 hypertension patients · 16 weeks
-11.5
mmHg systolic
-6.3
mmHg diastolic

That's more than many standard blood pressure pills achieve.

Active ingredient · Endothelium + Calcification

Hawthorn

The only herbal medicinal plant officially recognized by the German Commission E for heart complaints. Improves blood circulation in the coronary arteries, strengthens the heart muscle, and dilates blood vessels.

Study 2016 · 1,606 participants · 16 weeks · placebo-controlled
-3.49
mmHg systolic
-1.96
mmHg diastolic
Active ingredient · Calcification

Vitamin D3 + K2

D3 ensures that the body can absorb calcium from food at all. K2 directs the absorbed calcium into the bones — instead of into the vessel walls. Without K2, calcium is deposited in the arteries and causes calcification.

Study 2013 · Hypertensive Patients · Placebo-Controlled
-3.49
mmHg systolic
-1.96
mmHg diastolic

K2 can also extract existing calcium deposits from artery walls.

Back to product

A brief look at research

Hawthorn — the German Federal Institute for Drugs and Medical Devices' Commission E issued a monograph on hawthorn extract in 1994. The active ingredient complex of Vitex and OPC are well characterized.

Beetroot — Meta-analyses (2017, 2024) show an effect of beetroot juice on systolic blood pressure in hypertensive patients.

Turmeric — 35 RCTs in a meta-analysis (2023) show a small but significant effect on flow-mediated dilation and VCAM-1.

Vitamin K2 (MK-7) — the Rotterdam Study documented a correlation between K2 intake and cardiovascular mortality.

„The combination of five plant-based active ingredients and vitamins D3 + K2 makes RootPulse one of the most well-conceived formulas that I recommend to my patients for daily vitality."

— Dr. Katharina Berger · Specialist in Internal Medicine, Hamburg

What we do not claim

RootPulse is a food supplement—not a medicine. We do not claim that it cures, alleviates, or prevents diseases. All statements regarding immune function, muscle function, bones, and blood clotting are based on EU-approved health claims for vitamin D3 and K2.

For herbal ingredients, we rely on traditional use and the scientific literature on the bioavailability of sublingual forms—without promising individual clinical effects.